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The history of herbalism is closely tied with the history of medicine from prehistoric times up until the development of the germ theory of disease in the 19th century. Modern medicine from the 19th century to today has been based on evidence gathered using the scientific method. Evidence-based use of pharmaceutical drugs, often derived from medicinal plants, has largely replaced herbal treatments in modern health care. However, many people continue to employ various forms of traditional or alternative medicine. These systems often have a significant herbal component. The history of herbalism also overlaps with food history, as many of the herbs and spices historically used by humans to season food yield useful medicinal compounds, and use of spices with antimicrobial activity in cooking is part of an ancient response to the threat of food-borne pathogens.

The use of plants as medicines predates written human history. Archaeological evidence indicates that humans were using medicinal plants during the Paleolithic, approximately 60,000 years ago. (Furthermore, other non-human primates are also known to ingest medicinal plants to treat illness) Plant samples gathered from prehistoric burial sites have been thought to support the claim that Paleolithic people had knowledge of herbal medicine. For instance, a 60,000-year-old Neanderthal burial site, "Shanidar IV", in northern Iraq has yielded large amounts of pollen from 8 plant species, 7 of which are used now as herbal remedies. More recently Paul B. Pettitt has written that "A recent examination of the microfauna from the strata into which the grave was cut suggests that the pollen was deposited by the burrowing rodent Meriones tersicus, which is common in the Shanidar microfauna and whose burrowing activity can be observed today". Medicinal herbs were found in the per

Mesopotamia edit In Mesopotamia, the written study of herbs dates back over 5,000 years to the Sumerians, who created clay tablets with lists of hundreds of medicinal plants (such as myrrh and opium). Ancient Egypt edit Ancient Egyptian texts are of particular interest due to the language and translation controversies that accompany texts from this era and region. These differences in conclusions stem from the lack of complete knowledge of the Egyptian language: many translations are composed of mere approximations between Egyptian and modern ideas, and there can never be complete certainty of meaning or context. While physical documents are scarce, texts such as the Papyrus Ebers serve to illuminate and relieve some of the conjecture surrounding ancient herbal practices. The Papyrus consists of lists of ailments and their treatments, ranging from "disease of the limbs" to "diseases of the skin" and has information on over 850 plant medicines, including garlic, juni

While there are certainly texts from the medieval period that denote the uses of herbs, there has been a long-standing debate between scholars as to the actual motivations and understandings that underline the creation of herbal documents during the medieval period. The first point of view dictates that the information presented in these medieval texts were merely copied from their classical equivalents without much thought or understanding. The second viewpoint, which is gaining traction among modern scholars, states that herbals were copied for actual use and backed by genuine understanding. Some evidence for the suggestion that herbals were utilized with knowledgeable intent, was the addition of several chapters of plants, lists of symptoms, habitat information, and plant synonyms added to texts such as the Herbarium . Notable texts utilized in this time period include Bald's Leechbook, the Lacnunga, the peri didaxeon, Herbarium Apulei, Da Taxone, and Madicina de Quadrupedidus,

During the Middle Ages, the study of plants began to be based on critical observations. "In the 16th and 17th century an interest in botany revived in Europe and spread to America by way of European conquest and colonization." Philosophers started to act as herbalists and academic professors studied plants with great depth. Herbalists began to explore the use of plants for both medicinal purposes and agricultural uses. Botanists in the Middle Ages were known as herbalists; they collected, grew, dried, stored, and sketched plants. Many became experts in identifying and describing plants according to their morphology and habitats, as well as their usefulness. These books, called herbals included beautiful drawings and paintings of plants as well as their uses. At that time both botany and the art of gardening stressed the utility of plants for man; the popular herbal, described the medical uses of plants. During the Middle Ages, there was an expansion of book culture that sprea